2-Aminothiazole New
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What is 2-Aminothiazole
2-Aminothiazole, 2-Thiazolamine, molecular formula C3H4N2S, molecular weight 100.14, CAS number 96-50-4.
White to yellow crystal, turns dark brown when exposed to air, easy to sublime. Slightly soluble in cold water and ethanol, easily soluble in hot water and dilute inorganic acids. Avoid light. Avoid contact with strong oxidants, strong acids, acid chlorides and acid anhydrides.
2-Aminothiazole Numbering System
CAS Number: 96-50-4
MDL number: MFCD00005325
EINECS Number: 202-511-6
RTECS No.: XJ2100000
BRN number: 105738
PubChem number: 24846344
2-Aminothiazole Physical Properties
Appearance: White to yellow crystal, turns dark brown when exposed to air, easy to sublime.
Melting point (ºC): 90
Boiling point (ºC, 1.46kPa): 140
Solubility: slightly soluble in cold water and ethanol, easily soluble in hot water and dilute inorganic acids.
2-Aminothiazole Molecular Structural Data
1. Molar refractive index: 26.96
2. Molar volume (cm3/mol): 74.4
3. Isotonic specific volume (90.2K): 210.4
4. Surface tension (dyne/cm): 63.9
5. Polarizability (10-24cm3): 10.68
2-Aminothiazole Properties and Stability
Avoid light. Avoid contact with strong oxidants, strong acids, acid chlorides and acid anhydrides.
How to store 2-Aminothiazole
Store in a cool, ventilated warehouse. Keep away from fire and heat sources. Keep container tightly closed. It should be stored separately from oxidants, acids, and edible chemicals, and should not be mixed. Equipped with the appropriate variety and quantity of fire equipment. Storage areas should be provided with suitable materials to contain spills.
2-Aminothiazole synthetic method
It is obtained by cyclization of thiourea and chloroacetaldehyde (or ethanol and chlorine, or α, β dichloroethyl ether). The reactor was charged with hot water, thiourea and α,β-dichloroethyl ether. Reflux with stirring for 2h. After cooling, sodium hydroxide solution was added through a dropping funnel to make the solution alkaline, and 2-aminothiazole crystals were precipitated. Diethyl ether was then added to dissolve it. The ether layer was separated, washed with water, dried over anhydrous sodium sulfate, and the ether was evaporated to obtain the crude product. Recrystallization from ethanol gave yellow crystals. Yield 80%, melting point 90°C.
2-Aminothiazole Uses
For the synthesis of sulfathiazole and antithyroid drugs, and as an intermediate in organic synthesis.
2-Aminothiazole, 2-Thiazolamine, molecular formula C3H4N2S, molecular weight 100.14, CAS number 96-50-4.
White to yellow crystal, turns dark brown when exposed to air, easy to sublime. Slightly soluble in cold water and ethanol, easily soluble in hot water and dilute inorganic acids. Avoid light. Avoid contact with strong oxidants, strong acids, acid chlorides and acid anhydrides.
2-Aminothiazole Numbering System
CAS Number: 96-50-4
MDL number: MFCD00005325
EINECS Number: 202-511-6
RTECS No.: XJ2100000
BRN number: 105738
PubChem number: 24846344
2-Aminothiazole Physical Properties
Appearance: White to yellow crystal, turns dark brown when exposed to air, easy to sublime.
Melting point (ºC): 90
Boiling point (ºC, 1.46kPa): 140
Solubility: slightly soluble in cold water and ethanol, easily soluble in hot water and dilute inorganic acids.
2-Aminothiazole Molecular Structural Data
1. Molar refractive index: 26.96
2. Molar volume (cm3/mol): 74.4
3. Isotonic specific volume (90.2K): 210.4
4. Surface tension (dyne/cm): 63.9
5. Polarizability (10-24cm3): 10.68
2-Aminothiazole Properties and Stability
Avoid light. Avoid contact with strong oxidants, strong acids, acid chlorides and acid anhydrides.
How to store 2-Aminothiazole
Store in a cool, ventilated warehouse. Keep away from fire and heat sources. Keep container tightly closed. It should be stored separately from oxidants, acids, and edible chemicals, and should not be mixed. Equipped with the appropriate variety and quantity of fire equipment. Storage areas should be provided with suitable materials to contain spills.
2-Aminothiazole synthetic method
It is obtained by cyclization of thiourea and chloroacetaldehyde (or ethanol and chlorine, or α, β dichloroethyl ether). The reactor was charged with hot water, thiourea and α,β-dichloroethyl ether. Reflux with stirring for 2h. After cooling, sodium hydroxide solution was added through a dropping funnel to make the solution alkaline, and 2-aminothiazole crystals were precipitated. Diethyl ether was then added to dissolve it. The ether layer was separated, washed with water, dried over anhydrous sodium sulfate, and the ether was evaporated to obtain the crude product. Recrystallization from ethanol gave yellow crystals. Yield 80%, melting point 90°C.
2-Aminothiazole Uses
For the synthesis of sulfathiazole and antithyroid drugs, and as an intermediate in organic synthesis.
What is 2-Aminothiazole
2-Aminothiazole, 2-Thiazolamine, molecular formula C3H4N2S, molecular weight 100.14, CAS number 96-50-4.
White to yellow crystal, turns dark brown when exposed to air, easy to sublime. Slightly soluble in cold water and ethanol, easily soluble in hot water and dilute inorganic acids. Avoid light. Avoid contact with strong oxidants, strong acids, acid chlorides and acid anhydrides.
2-Aminothiazole Numbering System
CAS Number: 96-50-4
MDL number: MFCD00005325
EINECS Number: 202-511-6
RTECS No.: XJ2100000
BRN number: 105738
PubChem number: 24846344
2-Aminothiazole Physical Properties
Appearance: White to yellow crystal, turns dark brown when exposed to air, easy to sublime.
Melting point (ºC): 90
Boiling point (ºC, 1.46kPa): 140
Solubility: slightly soluble in cold water and ethanol, easily soluble in hot water and dilute inorganic acids.
2-Aminothiazole Molecular Structural Data
1. Molar refractive index: 26.96
2. Molar volume (cm3/mol): 74.4
3. Isotonic specific volume (90.2K): 210.4
4. Surface tension (dyne/cm): 63.9
5. Polarizability (10-24cm3): 10.68
2-Aminothiazole Properties and Stability
Avoid light. Avoid contact with strong oxidants, strong acids, acid chlorides and acid anhydrides.
How to store 2-Aminothiazole
Store in a cool, ventilated warehouse. Keep away from fire and heat sources. Keep container tightly closed. It should be stored separately from oxidants, acids, and edible chemicals, and should not be mixed. Equipped with the appropriate variety and quantity of fire equipment. Storage areas should be provided with suitable materials to contain spills.
2-Aminothiazole synthetic method
It is obtained by cyclization of thiourea and chloroacetaldehyde (or ethanol and chlorine, or α, β dichloroethyl ether). The reactor was charged with hot water, thiourea and α,β-dichloroethyl ether. Reflux with stirring for 2h. After cooling, sodium hydroxide solution was added through a dropping funnel to make the solution alkaline, and 2-aminothiazole crystals were precipitated. Diethyl ether was then added to dissolve it. The ether layer was separated, washed with water, dried over anhydrous sodium sulfate, and the ether was evaporated to obtain the crude product. Recrystallization from ethanol gave yellow crystals. Yield 80%, melting point 90°C.
2-Aminothiazole Uses
For the synthesis of sulfathiazole and antithyroid drugs, and as an intermediate in organic synthesis.
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